Tailored Particles

Particle engineering is of crucial relevance for the production of oral forms of poorly soluble drugs, as proven by the micronized and more recently nanosized formulations which have been marketed.

A fine and tunable control of particle size and morphology is also required for the development of inhalable drugs, injectable suspension, combination therapies and challenging drugs with a narrow therapeutic index.

Nevertheless, tailored and differentiated drug particles with low solvent residues can be difficult to produce in a reliable way by currently available techniques such as crystallization or milling, thus hindering the development of new chemical entities and enhanced formulations of off-patent drugs.

 
Some applications of our supercritical fluid technology platform for particle engineering :

  • Tailored particles for inhaled therapy
  • Polymorph screening
  • Improved bioavailability of poorly soluble drugs
  • Stabilization and sustained-release delivery of biopharmaceuticals
  • Solid dispersion microparticles
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